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KMID : 0378019740170111531
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New Medical Journal
1974 Volume.17 No. 11 p.1531 ~ p.1538
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Hypnotics- Induced Fatty Livers in the Rat
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高光三/Koh, K.S.
趙萬熙/高宇永/金明聖/Cho, M.H./Koh, U.Y./Kim, M.S.
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Abstract
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As a result of phenobarbital, amobarbital and chloropromazine administration to rats fed a standard laboratory diet, the levels of triglycerides phospholipids and total cholesterol in the livers and serum and pancreatic and serumlipase activity were changed in these animals.
Phenobarbital and amobarbitalproduced elevated levels of triglycerides, phospholipids and total cholesterol in the livers and level of triglycerides in the serum, but lowered levels of phospholipids and total cholesterol in the serum were produced. Chloropromazine produced slightly lowered levels of triglycerides, phospholipids and total cholesterol in the serum, but levels in the livers were not influenced.
The level of pancreatic lipase was not affected by admininstration of phenobarbitai and amobar￢bital, but the level of serum lipase was elevated in twofold.
Administration of chloropromazine produced elevated level of serum lipase and lowered level ´ of pancreatic lipase.
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